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KMID : 0377619900550020097
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Korean Jungang Medical Journal
1990 Volume.55 No. 2 p.97 ~ p.102
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On the Antibiotic Resistance of Staphylococcus aureus Clinically Isolated
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Abstract
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This study was carried out to study the resistant gene evolution of the methicillinresistant Staphylococcus aureus (MRSA) and the mechanism of vancomycin-resistant Staphylococcus aureus in MRSA strains.
Minimal inhibitory concentration (MIC) test of 48 strains which were isolated from two general hospitals at Kwang Ju City, Korea to 9 antibiotics; five 0-lactams, kanamycin, tetracyclin, chloramphenicol and vancomycin, was evaluated by using agar dilution method.
The results obtained are as following;
According to test of MIC distribution on 9 antibiotics against S. aureus, -lactams ranged from 0.39 to > 500 g/ml, chloramphenicol ranged from 3.13 to 250 g/ml, tetracyclin ranged from 6.25 to 500 g/ml, kanamycin ranged from 12.5 to > 500 pg/ml and vancomycin ranged from 3.13 to > 500 g/ml.
Among these antibiotics, vancomycin showed excellent antimicrobial activities to clinical isolates of S. aureus. Vancomycin-sensitive strain was isolated from vancomycinresistant strain which was isolated from clinical isolates of MRSA strain with treatment at 43.50C.
MIC distributions of the vancomycin-sensitive S. aureus strain are as followings; MIC of vancomycin-resistant strain to -lactams ranged from 6.25 g/ml to > 500 g/m1, but vancomycin-sensitive strain ranged from 0.39 g/ml to 1.56 g/ml. MIC of vancomycin-sensitive strain against chloramphenicol was 3.13 g/ml, tetracyclin was 0.78 pg/ml, kanamycin was 1.56 g/ml and vancomycin was 1.56 g/ml respectively.
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KEYWORD
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